O-Desmethyl carvedilol

CAS: 72956-44-6

Ref. 3D-FD21247

Product Information

• Name: O-Desmethyl carvedilol
• Synonyms: 2-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]phenolBM 14242Desmethylcarvedilol, Phenol, 2-(2-((3-(9H-carbazol-4-yloxy)-2-hydroxypropyl)amino)ethoxy)-

Description

O-Desmethyl Carvedilol is a metabolite of Carvedilol, which is an effective oral anti-hypertensive agent. O-Desmethyl Carvedilol is a potent inhibitor of the hepatic cytochrome P450 system and inhibits the activity of human liver microsomes at concentrations of 10 μM. The LC-MS/MS method for measuring O-Desmethyl Carvedilol in urine samples has been validated and found to be accurate and precise. Clinical studies have shown that carvedilol has a profile of lipid lowering, vasodilation, and anti-ischaemic effects with relatively few side effects. Studies have also shown that carvedilol is metabolized by the liver into active metabolites such as O-desmethyl carvadiol (ODC).

• Brand: Biosynth

Chemical properties

• Molecular weight: 392.45 g/mol
• Formula: C₂₃H₂₄N₂O₄
• Purity: Min. 95%
• InChI: InChI=1S/C23H24N2O4/c26-16(14-24-12-13-28-21-10-4-3-9-20(21)27)15-29-22-11-5-8-19-23(22)17-6-1-2-7-18(17)25-19/h1-11,16,24-27H,12-15H2
• InChI key: InChIKey=XAUKPPPYYOKVQJ-UHFFFAOYSA-N
• SMILES: Oc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12