Desmethyl lacosamide

CAS: 175481-38-6

Ref. 3D-FD21285

Product Information

• Name: Desmethyl lacosamide
• Synonyms: (2R)-2-(Acetylamino)-3-hydroxy-N-(phenylmethyl)propanamideN-Acetyl-D-serine benzyl amide, (2R)-2-(Acetylamino)-3-hydroxy-N-(phenylmethyl)propanamide, (R)-N-Benzyl-2-acetamido-3-hydroxypropionamide, (2R)-N-Benzyl-2-acetamido-3-hydroxypropanamide, Propanamide, 2-(acetylamino)-3-hydroxy-N-(phenylmethyl)-, (R)-, Propanamide, 2-(acetylamino)-3-hydroxy-N-(phenylmethyl)-, (2R)-

Description

Lacosamide is an antiepileptic drug that has been shown to be bioequivalent to the reference product, Gabapentin. Lacosamide binds to voltage-gated sodium channels and is thought to have a similar clinical profile as Gabapentin. It is used in the treatment of partial seizures (with or without secondary generalization) and adjunctive therapy for generalized seizures in adults and children aged 2 years or older. Lacosamide can interact with other drugs, such as gabapentin, by increasing their serum concentrations. This interaction may lead to adverse effects such as dizziness and confusion. Lacosamide plasma concentrations are measured using LC-MS/MS methods after a two-way crossover study in healthy human volunteers. This study also showed that lacosamide is excreted unchanged in urine samples at a rate of about 50% over 24 hours, indicating that it does not undergo extensive metabolism in humans.

• Brand: Biosynth

Chemical properties

• Molecular weight: 236.27 g/mol
• Formula: C₁₂H₁₆N₂O₃
• Purity: Min. 95%
• Color/Form: White Off-White Powder
• InChI: InChI=1S/C12H16N2O3/c1-9(16)14-11(8-15)12(17)13-7-10-5-3-2-4-6-10/h2-6,11,15H,7-8H2,1H3,(H,13,17)(H,14,16)/t11-/m1/s1
• InChI key: InChIKey=XRKSCJLQKGLSKU-LLVKDONJSA-N
• SMILES: CC(=O)N[C@H](CO)C(=O)NCc1ccccc1