2,4-Diamino-6-hydroxy-5-nitropyrimidine
CAS: 3346-23-4
Ref. 3D-FD21462
| 1g | 376.00 € | ||
| 2g | 550.00 € | ||
| 5g | 1,025.00 € | ||
| 250mg | 179.00 € | ||
| 500mg | 272.00 € |
Product Information
- 2,6-Diamino-5-nitroso-4-pyrimidinolNsc44924
- 2,6-Diamino-5-nitropyrimidin-4(3H)-one
- 4(3H)-pyrimidinone, 2,6-diamino-5-nitro-
2,4-Diamino-6-hydroxy-5-nitropyrimidine is an anticancer agent that has been shown to be effective against both bone and colorectal cancers. It inhibits the growth of cancer cells by inducing caspase-independent cell death, which occurs in a pd-l1 dependent manner. This agent also has minimal toxicity in vitro, as it induces cell lysis at high concentrations. 2,4-Diamino-6-hydroxy-5-nitropyrimidine is not active against normal cells.
2,4-Diamino-6-hydroxy-5-nitropyrimidine induces mitochondrial membrane depolarization and mitochondrial membrane potential loss in a dose dependent manner. These effects are likely responsible for the induction of caspase independent cell death seen with this drug.
Chemical properties
Technical inquiry about: 3D-FD21462 2,4-Diamino-6-hydroxy-5-nitropyrimidine
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