Dimethyl 2-ketoglutaconate

CAS: 13192-04-6

Ref. 3D-FD22239

Product Information

• Name: Dimethyl 2-ketoglutaconate
• Synonyms: a-Ketoglutaric acid dimethyl esterDimethyl 2-oxopentanedioate2-Oxo-pentanedioic acid 1,5-dimethyl ester, 1,5-Dimethyl 2-oxopentanedioate, 2-Ketoglutaric acid dimethyl ester, 2-Oxoglutaric acid dimethyl ester, Dimethyl 2-Oxopentanedioate, Dimethyl α-ketoglutarate, Dimethyl α-oxoglutarate, Glutaric acid, 2-oxo-, dimethyl ester, Pentanedioic acid, 2-oxo-, 1,5-dimethyl ester, Pentanedioic acid, 2-oxo-, dimethyl ester, α-Ketoglutaric acid dimethyl ester

Description

Dimethyl 2-ketoglutaconate (DMG) is an intermediate in the Krebs cycle and is a precursor for the production of glutamate, which is an important neurotransmitter. DMG has been shown to induce autophagy, a process by which cells clear out damaged proteins, organelles, and other cellular components. This process may be important in the treatment of various cancers such as cervical cancer or solid tumours. DMG has also been shown to inhibit hif-1α, a transcription factor that regulates many genes including those involved in tumor growth and metabolism. The effect of DMG on carcinoma cells can be enhanced with benzodiazepine binding. A study found that DMG was able to inhibit tumor growth in prostate cancer cells through metabolic changes that were not observed in normal cells. It also showed antiproliferative effects on human carcinoma cell lines induced by DMBA or benzo[a]pyrene treatments.

• Brand: Biosynth

Chemical properties

• Molecular weight: 174.15 g/mol
• Formula: C₇H₁₀O₅
• Purity: Min. 95%
• Color/Form: Clear Liquid
• InChI: InChI=1S/C7H10O5/c1-11-6(9)4-3-5(8)7(10)12-2/h3-4H2,1-2H3
• InChI key: InChIKey=TXIXSLPEABAEHP-UHFFFAOYSA-N
• SMILES: COC(=O)CCC(=O)C(=O)OC