3,5-Difluoro-4-pyridinecarboxaldehyde
CAS: 870234-98-3
Ref. 3D-FD32269
1g | Discontinued | ||
50mg | Discontinued | ||
100mg | Discontinued | ||
250mg | Discontinued | ||
500mg | Discontinued |
Product Information
- 3,5-Difluoroisonicotinaldehyde
- 4-Pyridinecarboxaldehyde, 3,5-Difluoro-
- 3,5-Difluoropyridine-4-Carbaldehyde
The synthesis of 3,5-difluoro-4-pyridinecarboxaldehyde is an efficient and high yielding process. In the first step, n-fluorobenzenesulfonimide reacts with pyridine in a transmetallation reaction to give the corresponding difluorinated pyridine. The difluorinated pyridine is then reacted with difluoroethanal to give 3,5-difluoro-4-pyridinecarboxaldehyde. The yield of this reaction is approximately 95%. This reaction can be carried out at low temperatures (0°C) and can be used to produce the target compound in large quantities.