3,5-Diamino-1,2,4-triazole

CAS: 1455-77-2

Ref. 3D-FD32366

Product Information

• Name: 3,5-Diamino-1,2,4-triazole
• Synonyms: 1H-1,2,4-triazole-3,5-diamine, 3,5-Diamino-1,2,4-triazole (Guanazole), 3,5-Diamino-1H-1,2,4-triazole, 3,5-Diamino-s-triazole, Guanazole, NSC 166592, NSC 167391, NSC 167392, NSC 1895

Description

3,5-Diamino-1,2,4-triazole is a nitrogen heterocyclic compound that has shown to be an inhibitor of the Toll-like receptor (TLR) signaling pathway. The TLR pathway is a major regulator of the innate immune system and plays a role in the development of many infectious diseases. 3,5-Diamino-1,2,4-triazole has been shown to inhibit bacterial growth in model systems and leukemic mice. It is also shown to have high binding affinity for TLRs. 3,5-Diamino-1,2,4-triazole binds to the Toll/interleukin 1 receptor domain (TIR) by hydrogen bonding interactions with amino acid residues and competitively inhibits the binding of ligands such as lipopolysaccharide (LPS) or peptidoglycan. This inhibition leads to reduced production of proinflammatory cytokines such as IL-8 and

• Brand: Biosynth

Chemical properties

• Molecular weight: 99.09 g/mol
• Formula: C₂H₅N₅
• Purity: Min. 95%
• InChI: InChI=1S/C2H5N5/c3-1-5-2(4)7-6-1/h(H5,3,4,5,6,7)
• InChI key: InChIKey=PKWIYNIDEDLDCJ-UHFFFAOYSA-N
• SMILES: Nc1n[nH]c(N)n1