2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

CAS: 213697-53-1

Ref. 3D-FD44739

Product Information

• Name: 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
• Synonyms: DavePhos, (2-Dimethylamino-1,1′-biphenyl-2-yl)dicyclohexylphosphine, 2-(2-Dicyclohexylphosphanylphenyl)-N,N-dimethylaniline, 2-(Dicyclohexylphosphino)-2′-(dimethylamino)biphenyl, 2-(N,N-Dimethylamino)-2′-(dicyclohexylphosphino)biphenyl, 2-Dicyclohexylphosphino-2′-dimethylamino-1,1′-biphenyl, 2-[2-(Dicyclohexylphosphanyl)phenyl]-N,N-dimethylaniline, 2′-(Dicyclohexylphosphanyl)-N,N-dimethylbiphenyl-2-amine, 2′-(Dicyclohexylphosphino)-N,N-dimethyl-[1,1′-biphenyl]-2-amine, 2′-(Dicyclohexylphosphino)-N,N-dimethylbiphenyl-2-amine, Dave-Phos, Dicyclohexyl[2′-(dimethylamino)biphenyl-2-yl]phosphine, [1,1′-Biphenyl]-2-amine, 2′-(dicyclohexylphosphino)-N,N-dimethyl-

Description

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl is a potent inhibitor of the enzyme bromodomain. Bromodomain has been implicated in cancer and other diseases. 2-DCPB binds to the bromodomain in a covalent manner, blocking the ATP site and inhibiting bromodomain function. This inhibition has been shown to be selective for bromodomains over other domains. In addition, 2-DCPB acts as a growth regulator by binding to Toll-like receptor 4 (TLR4), which is important in cytokine signaling. 2-DCPB also inhibits allyl carbonate production and cross coupling reactions between aryl chlorides and nitrogen atoms or amines. 2-DCPB has an inhibitory effect on depression, but this effect is not related to its inhibitory effect on bromodomains.

• Brand: Biosynth

Chemical properties

• Molecular weight: 393.54 g/mol
• Formula: C₂₆H₃₆NP
• Purity: Min. 95%
• Color/Form: White To Yellow Solid
• InChI: InChI=1S/C26H36NP/c1-27(2)25-19-11-9-17-23(25)24-18-10-12-20-26(24)28(21-13-5-3-6-14-21)22-15-7-4-8-16-22/h9-12,17-22H,3-8,13-16H2,1-2H3
• InChI key: InChIKey=ZEMZPXWZVTUONV-UHFFFAOYSA-N
• SMILES: CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1