Digoxigenin NHS-ester

CAS: 129273-26-3

Ref. 3D-FD45749

Product Information

• Name: Digoxigenin NHS-ester
• Synonyms: epsilon-(Digoxigenin-3-O-acetamido)caproic acid N-hydroxysuccinimide ester
• Brand: Biosynth
• Description: Digoxigenin is a fluorescent molecule that binds to the neurokinin-1 receptor. It has been used as an experimental model for cardiac tissue culture. Digoxigenin NHS-ester is a fluorescent derivative of digoxigenin that has been used to study the uptake and distribution of this compound in various tissues, including the heart. Digoxigenin NHS-ester binds to collagen and other extracellular matrix proteins and can be detected by immunofluorescence. In addition, it has been shown to stimulate growth factor release from cardiomyocytes. The fluorescence properties of digoxigenin NHS-ester can be measured using a fluorimeter with an excitation wavelength of 350 nm and emission wavelength of 450 nm. This molecule is also used as a marker for cell proliferation, because its accumulation in cells increases during cell division. The binding affinity of digoxigenin NHS-ester for neurokinin receptors is dependent on intramolecular hydrogen bonds formed between the amide

Chemical properties

• Molecular weight: 658.78 g/mol
• Formula: C₃₅H₅₀N₂O₁₀
• Purity: Min. 95%
• Color/Form: Powder