Diethyl methylmalonate

CAS: 609-08-5

Ref. 3D-FD52504

Product Information

• Name: Diethyl methylmalonate
• Synonyms: Diethyl 2-methylpropanedioateMethylmalonic acid diethyl ester, 1,3-Diethyl 2-methylpropanedioate, 2-Methyl-Malonicaciddiethylester, 2-Methyl-Propanedioicaciddiethylester, 2-Methylmalonic acid diethyl ester, Diethyl 2-Methylpropanedioate, Diethyl 2-methylmalonate, Diethyl Methylmalonate 99% (Gc), Diethyl methylpropanedioate, Diethyl α-methylmalonate, Diethylisosuccinate, Diethylmethylmalonat, Diethylmethylmalonate,99%, Dlethylmethylmalonate, Ethyl methylmalonate, Malonate, Methyl-, Diethyl, Malonic acid, methyl-, diethyl ester, Methoxymalonic Acid Diethyl Ester, Methyl-Propanedioicacidiethylester, Methylmalonate de diethyle, Methylmalonic Acid Diethyl Ester, Methylmalonic acid diethyl ester~Methylpropanedioic acid diethyl ester, Metilmalonato De Dietilo, Nsc 8700, Propanedioic acid, 2-methyl-, 1,3-diethyl ester, Propanedioic acid, 2-methyl-, diethyl ester, Propanedioic acid, methyl-, diethyl ester, Rarechem Al Bi 0301

Description

Diethyl methylmalonate is an organic compound with the chemical formula CH3COCH2COOC2H5. It is a sodium salt of diethyl methylmalonate, which is a nitrite ion donor. Diethyl methylmalonate has been used to catalyze the palladium-catalyzed coupling of alkanoic acids and methylmalonic acid in the presence of triethylamine. This reaction converts the alkanoic acid into an ester and methylmalonic acid into an alcohol. The reaction mechanism for this process involves a transfer reaction from diethyl methylmalonate to the alkanoic acid followed by nucleophilic substitution at carbon atom 2 of the alkanocarboxylic acid by methyll malonyl chloride (see figure).

The resulting ester undergoes hydrolysis to give picolinic acid and dibromomethane, which is then oxidized with nitrite ion to give

• Brand: Biosynth

Chemical properties

• Molecular weight: 174.19 g/mol
• Formula: C₈H₁₄O₄
• Purity: Min. 95%