3,5-Difluorophenylacetic acid

CAS: 105184-38-1

Ref. 3D-FD63975

Product Information

• Name: 3,5-Difluorophenylacetic acid
• Synonyms: 2-(3,5-Difluorophenyl)acetic acid, 3.5-Difluoro phenyl acetic acid, 3,5-Difluoro phenyl acetic acid, (3,5-Difluorophenyl)Acetate, 2-(3,5-Difluorophenyl)Acetic Acid, 6-fluoro-4H-chromen-4-one, 3,5-Difluoro-Benzeneacetic acid

Description

3,5-Difluorophenylacetic acid is a compound that inhibits the activity of the enzyme α-ketoglutarate dehydrogenase (KGD) in vitro and in vivo. 3,5-Difluorophenylacetic acid has shown inhibitory properties against KGD in vitro assays with an IC 50 of 0.6 mM. In vivo tests have also been conducted showing that 3,5-difluorophenylacetic acid inhibited KGD activity in the brain with an IC 50 of 1.2 mM. The inhibition of KGD by 3,5-difluorophenylacetic acid may be due to its photochemical properties and the fact that it is an oxalyl chloride substrate.
3,5-Difluorophenylacetic acid has also been shown to be a γ-secretase inhibitor which means it could be effective for Alzheimer's disease treatment as well as other neurodeg

• Brand: Biosynth

Chemical properties

• Molecular weight: 172.13 g/mol
• Formula: C₈H₆F₂O₂
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C8H6F2O2/c9-6-1-5(3-8(11)12)2-7(10)4-6/h1-2,4H,3H2,(H,11,12)
• InChI key: InChIKey=IGGNSAVLXJKCNH-UHFFFAOYSA-N
• SMILES: O=C(O)Cc1cc(F)cc(F)c1