2,2'-Dihydroxy-6,6'-dinaphthyldisulphide

CAS: 6088-51-3

Ref. 3D-FD67127

Product Information

• Name: 2,2'-Dihydroxy-6,6'-dinaphthyldisulphide
• Synonyms: DDD6-Hydroxy-2-naphthyl disulfide6-[(6-Hydroxy-2-naphthyl)disulfanyl]naphthalen-2-ol6-[(6-Hydroxy-2-naphthyl)disulfanyl]-2-naphth ol
• Brand: Biosynth

Description

2,2'-Dihydroxy-6,6'-dinaphthyldisulphide (DIDS) is a potent surfactant that can be used to induce inflammation and tissue damage in an animal model. This compound is also reactive in the presence of histochemical stains. DIDS reacts with disulfides found in the cytoplasm of cells to produce sulfenic acid intermediates. These intermediates are then converted into sulphonic acid by oxidation, which results in histochemical staining of tissues. Abdominal tissue samples stained with DIDS show a decrease in the number of neutrophils and macrophages as well as an increase in mast cells. Histochemical staining has been shown to be useful for diagnosing autoimmune diseases such as Crohn's disease or ulcerative colitis.

Chemical properties

• Molecular weight: 350.46 g/mol
• Formula: C₂₀H₁₄O₂S₂
• Purity: Min. 95%
• Color/Form: Powder