5-Demethylnobiletin

CAS: 2174-59-6

Ref. 3D-FD74228

Product Information

• Name: 5-Demethylnobiletin
• Synonyms: 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one5-Hydroxy 3?,4?,6,7,8-pentamethoxyflavone, 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one, 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxychromen-4-one, 4H-1-benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-, 5-Desmethylnobiletin, 5-Hydroxy-3′,4′,6,7,8-pentamethoxyflavone, 5-Hydroxy-6,7,8,3′,4′-pentamethoxyflavone, 5-O-Demethylnobiletin, 5-O-Desmethylnobiletin, Flavone, 5-hydroxy-3′,4′,6,7,8-pentamethoxy-, NSC 618927

Description

5-Demethylnobiletin is a coumarin derivative that inhibits the activity of protein tyrosine phosphatases (PTPs). It is synthesized by the condensation of caffeic acid and 3,4-dimethoxybenzaldehyde to form 5-hydroxy-2-(3,4-dimethoxyphenyl)acetaldehyde. The compound has been found to inhibit PTP1B and PTPN12 in vitro. In vivo studies have demonstrated that 5-demethylnobiletin increases autophagy in mouse liver cells. Electrophysiological analysis of hl-60 cells has also shown that 5-demethylnobiletin induces mitochondrial membrane potential loss, leading to apoptosis. The compound can be used as an analytical reagent for hplc with a preparative column and as a probe for receptor activity in vivo models. The compound's natural compounds can be used as pharmacological agents for treatment of diseases such as cancer or

• Brand: Biosynth

Chemical properties

• Molecular weight: 388.37 g/mol
• Formula: C₂₀H₂₀O₈
• Purity: Min. 95%
• Color/Form: Solid
• InChI: InChI=1S/C20H20O8/c1-23-12-7-6-10(8-14(12)24-2)13-9-11(21)15-16(22)18(25-3)20(27-5)19(26-4)17(15)28-13/h6-9,22H,1-5H3
• InChI key: InChIKey=DOFJNFPSMUCECH-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2cc(=O)c3c(O)c(OC)c(OC)c(OC)c3o2)cc1OC