Eplivanserin

CAS: 130579-75-8

Ref. 3D-FE102705

Product Information

• Name: Eplivanserin
• Synonyms: (Z,E)-1-(2-Fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime, 2-Propen-1-one, 1-(2-fluorophenyl)-3-(4-hydroxyphenyl)-, O-[2-(dimethylamino)ethyl]oxime, (1Z,2E)-, 2-Propen-1-one, 1-(2-fluorophenyl)-3-(4-hydroxyphenyl)-, O-[2-(dimethylamino)ethyl]oxime, (Z,E)-, 4-[(2Z)-3-{[2-(dimethylamino)ethoxy]amino}-3-(2-fluorophenyl)prop-2-en-1-ylidene]cyclohexa-2,5-dien-1-one, Sr 46349

Description

Eplivanserin is a potent and selective 5-HT2C receptor antagonist with pharmacological effects that include long-term efficacy. It has been shown to be effective in experimental models for treating depression, anxiety, and obsessive-compulsive disorder. Eplivanserin is also an antagonist of the α1A subunit of the histamine H1 receptor. It has been shown to reduce locomotor activity in rats and prevent lysis of erythrocytes from human blood by complement. The drug binds to the active site of polymerase chain reaction (PCR) DNA synthesis and blocks transcription elongation. This prevents mRNA transcription and protein synthesis at the ribosome level.
Eplivanserin is a 5-HT2C receptor agonist that selectively activates 5-HT2C receptors in the central nervous system, as well as in peripheral tissues such as the gastrointestinal tract, bladder, and uterus. Studies have shown that eplivanser

• Brand: Biosynth

Chemical properties

• Molecular weight: 328.38 g/mol
• Formula: C₁₉H₂₁FN₂O₂
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C19H21FN2O2/c1-22(2)13-14-24-21-19(17-5-3-4-6-18(17)20)12-9-15-7-10-16(23)11-8-15/h3-12,23H,13-14H2,1-2H3/b12-9+,21-19-
• InChI key: InChIKey=VAIOZOCLKVMIMN-PRJWTAEASA-N
• SMILES: CN(C)CCO/N=C(/C=C/c1ccc(O)cc1)c1ccccc1F