2-Ethynylbenzoic acid
CAS: 33578-00-6
Ref. 3D-FE12473
| 100g | 2,142.00 € | ||
| 50mg | 77.00 € | ||
| 100mg | 111.00 € | ||
| 250mg | 179.00 € | ||
| 500mg | 236.00 € |
Product Information
2-Ethynylbenzoic acid is an organic compound with a carboxylic acid functional group. It is an efficient method for the synthesis of amides from primary and secondary alcohols in the presence of a chloride donor, such as thionyl chloride. The reaction system is typically carried out in an organic solvent, such as dichloromethane or chloroform. The reaction mechanism proceeds by protonation of the alkene followed by nucleophilic attack by the amine on the carbonyl carbon atom. This step forms a tetrahedral intermediate that tautomerizes to give a furyl intermediate. The furyl intermediate then undergoes oxidative carbonylation to form 2-ethynylbenzaldehyde, which reacts with the amine to form 2-ethynylbenzoic acid. In this process, stereoselectivity can be achieved by using an acceptor that favors one enantiomer of 2-ethynylbenzaldehyde
Chemical properties
Technical inquiry about: 3D-FE12473 2-Ethynylbenzoic acid
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