Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

CAS: 161797-99-5

Ref. 3D-FE15829

Product Information

• Name: Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
• Synonyms: 2-(4-Hydroxyphenyl)-4-Methylthiazole-5-Carboxylate, 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester, 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxytic acid ethyl ester, 5-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-4-methyl-, ethyl ester, Ethyl 2-(4-HydroxyPhenyl)-4-Methyl Thiazole-5-Carboxylate, Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate, Ethyl-2-(4-Hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate, Ethyl2-(4-hydroxy phenyl)-4-methylthiazole-5-carboxylate, Febuxostat N-2

Description

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is an anticancer agent that belongs to the class of formamidines. It is synthesized by refluxing ethyl 4-hydroxyphenylacetic acid with hexamethylenetetramine and acetic acid in ethanol. After purification, it is converted to its active form by reacting with hydrochloric acid. Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate prevents the growth of cancer cells in culture by preventing DNA synthesis, which prevents RNA and protein synthesis. This agent has also been found to suppress paclitaxel production in cultured human breast cancer cells.

• Brand: Biosynth

Chemical properties

• Molecular weight: 263.31 g/mol
• Formula: C₁₃H₁₃NO₃S
• Purity: Min. 95%
• InChI: InChI=1S/C13H13NO3S/c1-3-17-13(16)11-8(2)14-12(18-11)9-4-6-10(15)7-5-9/h4-7,15H,3H2,1-2H3
• InChI key: InChIKey=LOCYSKNNFCGDTR-UHFFFAOYSA-N
• SMILES: CCOC(=O)c1sc(-c2ccc(O)cc2)nc1C