Epothilone A

CAS: 152044-53-6

Ref. 3D-FE22750

Product Information

• Name: Epothilone A
• Synonyms: (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[ 14.1.0]heptadecane-5,9-dione(-)-Epothilone AEpothilone A, (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione, (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione, 4,17-Dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1S,3S,7S,10R,11S,12S,16R)-, 4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (1S,3S,7S,10R,11S,12S,16R)-, 4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12-tetramethyl-3-[1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, [1R*,3R*(E),7R*,10S*,11R*,12R*,16S*]-, Epo A
• CAS: 152044-53-6

Description

Epothilone A is an anti-cancer drug that inhibits the mcl-1 protein, which is a member of the Bcl-2 family. Epothilone A binds to the BH3 domain of the mcl-1 protein and prevents it from binding to proapoptotic proteins, such as Bax. This inhibition leads to apoptosis in cancer cells. Epothilone A has been shown to have clinical properties in the treatment of inflammatory bowel disease, with a low toxicity profile. It also reduces angiogenesis by binding to epidermal growth factor (EGF) receptors at the cell surface and blocking EGF-induced activation of signaling pathways.

• Brand: Biosynth

Chemical properties

• Molecular weight: 493.66 g/mol
• Formula: C₂₆H₃₉NO₆S
• Purity: Min. 95%