Eslicarbazepine acetate

CAS: 236395-14-5

Ref. 3D-FE22807

Product Information

• Name: Eslicarbazepine acetate
• Synonyms: (10S)-10-(Acetyloxy)-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide(S)-(-)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carb oxamideBIA 2-093, (10S)-10-(Acetyloxy)-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide, (S)-(-)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide, (S)-(-)-10-Acetoxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide, (S)-5-Carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate, 5H-Dibenz[b,f]azepine-5-carboxamide, 10-(acetyloxy)-10,11-dihydro-, (10S)-, Aptiom, Bia 2-093, Eslicarbazepine Acetate, Exalief, Exelief, Sep 0002093, Zebinix

Description

Eslicarbazepine acetate is an anticonvulsant drug that has been shown to be effective in reducing the frequency of seizures. It is a prodrug and is metabolized by esterases to form the active form, eslicarbazepin acetate. Eslicarbazepine acetate inhibits glutamate release by acting on the glutamate transporter, which prevents depolarization of the mitochondrial membrane potential, leading to inhibition of epileptic activity. Eslicarbazepine acetate also decreases brain levels of GABA and increases levels of polyamines such as spermidine and spermine, which are neuroprotective. There are some reports of hepatic impairment when eslicarbazepine acetate is used with other drugs that are metabolized through this organ (e.g., valproic acid).
Eslicarbazepine acetate can cause chemical stability issues when exposed to light or air due to oxidation reactions. It may also react

• Brand: Biosynth

Chemical properties

• Molecular weight: 296.32 g/mol
• Formula: C₁₇H₁₆N₂O₃
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C17H16N2O3/c1-11(20)22-16-10-12-6-2-4-8-14(12)19(17(18)21)15-9-5-3-7-13(15)16/h2-9,16H,10H2,1H3,(H2,18,21)/t16-/m0/s1
• InChI key: InChIKey=QIALRBLEEWJACW-INIZCTEOSA-N
• SMILES: CC(=O)O[C@H]1Cc2ccccc2N(C(N)=O)c2ccccc21