Ethacrynic acid

CAS: 58-54-8

Ref. 3D-FE22848

Product Information

• Name: Ethacrynic acid
• Synonyms: 2-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid[4-(2-Methylenebutyryl)-2,3-dichlorophenoxy]acetic acidCrinuril, (2,3-Dichloro-4-(2-Methylene-1-Oxobutyl)Phenoxy)-Acetic Acid, (4-(2-Methylenebutyryl)-2,3-Dichlorophenoxy)Acetic Acid, 2,3-Dichloro-4-(2-Methylenebutyryl)Phenoxyacetic Acid, 2,3-Dichloro-4-(2-ethyl-1-oxo-2-propenyl)-phenoxyacetic acid, 2-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid, 2-[2,3-Dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid, 4-(2-Methylenebutyryl)Phenoxyacetic Acid, Acetic acid, 2-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]-, Acetic acid, [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]-, Acetic acid, [2,3-dichloro-4-(2-methylenebutyryl)phenoxy]-, Acide Etacrynique, Acido Etacrinico, Crinuril, Crinuryl, Dethacrynic acid, Edecril, Edecrin, Edecrina, Endecril, Etacrinic Acid, Etacrynic acid, Etacrynsaure, Etakrinic Acid, Ethacrynic, Hidromedin, Hydromedin, Mingit, Mk-595, Nsc 624008, Nsc 85791, Otacril, Redmax, Reomax, Taladren, Uregit, [2,3-Dichloro-4-(2-methylenebutyryl)phenoxy]acetic acid, [[2,3-Dichloro-4-[2-(methylene)butanoyl]phenyl]oxy]acetic acid

Description

Ethacrynic acid is a non-competitive, reversible inhibitor of the Na+/K+-ATPase. It has been shown to be effective against cancer tissues and infectious diseases such as malaria, tuberculosis, and leishmaniasis. Ethacrynic acid inhibits 2,4-dichlorobenzoic acid (2,4-DCBA)-induced tumor growth in mice by inducing apoptosis in human leukemia cells. Ethacrynic acid also inhibits mitochondrial membrane potential and cellular physiology by decreasing the activity of enzymes which are involved in energy metabolism.

• Brand: Biosynth

Chemical properties

• Molecular weight: 303.14 g/mol
• Formula: C₁₃H₁₂Cl₂O₄
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
• InChI key: InChIKey=AVOLMBLBETYQHX-UHFFFAOYSA-N
• SMILES: C=C(CC)C(=O)c1ccc(OCC(=O)O)c(Cl)c1Cl