2-Ethyl-2-phenylmalonamide

CAS: 7206-76-0

Ref. 3D-FE23105

Product Information

• Name: 2-Ethyl-2-phenylmalonamide
• Synonyms: 2-Ethyl-2-phenyl-propanediamide2-Ethyl-2-phenylmalondiamidePhenylethylmalonamide
• Brand: Biosynth
• Description: 2-Ethyl-2-phenylmalonamide (2-EPMA) is a metabolite of primidone that acts as an inhibitor of glutamate dehydrogenase and may be used in the treatment of epilepsy. It has been shown to be effective in treating seizures caused by carbamazepine, phenobarbital, or phenytoin. 2-EPMA is also used to measure enzyme activities in serum, which can be used as a diagnostic tool for liver diseases. 2-EPMA is typically prepared for use as an enzyme inhibitor by diluting it with high salt or human serum. This compound may have carcinogenic potential and should not be administered with single doses greater than 100 mg/kg body weight. 2-EPMA interacts with many other drugs such as phenobarbital, phenytoin, and carbamazepine.

Chemical properties

• Molecular weight: 206.24 g/mol
• Formula: C₁₁H₁₄N₂O₂
• Purity: Min. 95%
• InChI: InChI=1S/C11H14N2O2/c1-2-11(9(12)14,10(13)15)8-6-4-3-5-7-8/h3-7H,2H2,1H3,(H2,12,14)(H2,13,15)
• InChI key: InChIKey=JFZHPFOXAAIUMB-UHFFFAOYSA-N
• SMILES: CCC(C(N)=O)(C(N)=O)c1ccccc1