7-Ethyl-10-hydroxycamptothecin

CAS: 86639-52-3

Ref. 3D-FE29579

Product Information

• Name: 7-Ethyl-10-hydroxycamptothecin
• Synonyms: SN-38
• Brand: Biosynth
• Description: 7-Ethyl-10-hydroxycamptothecin (also known as SN38) is a metabolite of irinotecan hydrochloride (CPT-11). SN38 is a topoisomerase I inhibitor and has potential applications as an anti-tumour agent however its water insolubility presents challenges in terms of bioavailability. Topoisomerase I relaxes the tightly bound DNA double helix and breaks one DNA strand to allow for DNA replication, the topoisomerase-DNA complex is short-lived and once DNA replication is complete topoisomerase reforms the DNA strand. SN38 prolongs the lifetime of the topoisomerase I-DNA complex and inhibits the DNA reforming step, as a result cleavage of the second DNA strand can occur leading to cell death.

Chemical properties

• Molecular weight: 392.4 g/mol
• Formula: C₂₂H₂₀N₂O₅
• Purity: Min. 98 Area-%
• Color/Form: Off-White Yellow Powder