7-Ethyl-10-hydroxycamptothecin

CAS: 86639-52-3

Ref. 3D-FE29579

Product Information

• Name: 7-Ethyl-10-hydroxycamptothecin
• Synonyms: SN-38, (19S)-10,19-Diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione, (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, (S)-Sn 38, 10-Hydroxy-7-ethylcamptothecin, 1H-Pyrano3,4:6,7Indolizino1,2-Bquinoline-3,14(4H,12H)-Dione, 4-Ethyl-4,10-Dihydroxy-, 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-, 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (S)-, 4,11-Diethyl-4,9-Dihydroxy-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione, 4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 7-Ethyl-10-Hydroxy Camptothecin, 7-Ethyl-10-Hydroxy-Camptothecine, 7-Ethyl-10-hydroxy-20(S)-camptothecin, 7-Ethyl-10-hydroxycamptothecine, Intermediate of Irinotecan 1, SN 38 (pharmaceutical), SN 38 lactone, Sn-38

Description

7-Ethyl-10-hydroxycamptothecin (also known as SN38) is a metabolite of irinotecan hydrochloride (CPT-11). SN38 is a topoisomerase I inhibitor and has potential applications as an anti-tumour agent however its water insolubility presents challenges in terms of bioavailability. Topoisomerase I relaxes the tightly bound DNA double helix and breaks one DNA strand to allow for DNA replication, the topoisomerase-DNA complex is short-lived and once DNA replication is complete topoisomerase reforms the DNA strand. SN38 prolongs the lifetime of the topoisomerase I-DNA complex and inhibits the DNA reforming step, as a result cleavage of the second DNA strand can occur leading to cell death.

• Brand: Biosynth

Chemical properties

• Molecular weight: 392.4 g/mol
• Formula: C₂₂H₂₀N₂O₅
• Purity: Min. 98 Area-%
• Color/Form: Off-White Yellow Powder