Ethyl 4,6-dichloronicotinate
CAS: 40296-46-6
Ref. 3D-FE33985
5g | 136.00 € | ||
10g | 197.00 € | ||
25g | 281.00 € | ||
50g | 440.00 € | ||
100g | 626.00 € |
Product Information
- 4,6-Dichloropyridine-3-Carboxylic Acid Ethyl Ester
- 4,6-Dichloronicotinic Acid Ethyl Ester
- Ethyl 4,6-Dichloronicotinate
- 2,4-Dichloro-5-carbethoxypyridine
- 4,6-Dichloronicotinic acid ethyl ester ,97%
- Ethyl 4,6-Dichloropyridine-3-Carboxylate
Ethyl 4,6-dichloronicotinate (EDCN) is a hybrid drug that can be used as a clinical drug for the treatment of cancers. EDCN has been shown to have an antiproliferative effect in hematopoietic cells and tumor cells. It is also able to inhibit tyrosine kinase activity and cellular proliferation by inducing apoptosis. EDCN has been shown to be a potent inhibitor of cancer cell growth in vitro and in vivo, with IC50 values ranging from 1 to 10 μM. This drug is active against leukemia, lymphoma, breast cancer, prostate cancer, colorectal cancer, and other cancers that are sensitive to inhibition by tyrosine kinase inhibitors. EDCN binds reversibly to DNA with high affinity and specificity through hydrogen bonding interactions between the nucleobases on its aromatic ring system and the purine bases on dsDNA. This binding inhibits transcription by blocking access of RNA polymerase II to DNA templates
Chemical properties
Technical inquiry about: 3D-FE33985 Ethyl 4,6-dichloronicotinate
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