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Ethyl 4,6-dichloronicotinate
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Ethyl 4,6-dichloronicotinate

CAS: 40296-46-6

Ref. 3D-FE33985

5g
136.00 €
10g
197.00 €
25g
281.00 €
50g
440.00 €
100g
626.00 €
Estimated delivery in United States, on Wednesday 8 Jan 2025

Product Information

Name:
Ethyl 4,6-dichloronicotinate
Synonyms:
  • 4,6-Dichloropyridine-3-Carboxylic Acid Ethyl Ester
  • 4,6-Dichloronicotinic Acid Ethyl Ester
  • Ethyl 4,6-Dichloronicotinate
  • 2,4-Dichloro-5-carbethoxypyridine
  • 4,6-Dichloronicotinic acid ethyl ester ,97%
  • Ethyl 4,6-Dichloropyridine-3-Carboxylate
Description:

Ethyl 4,6-dichloronicotinate (EDCN) is a hybrid drug that can be used as a clinical drug for the treatment of cancers. EDCN has been shown to have an antiproliferative effect in hematopoietic cells and tumor cells. It is also able to inhibit tyrosine kinase activity and cellular proliferation by inducing apoptosis. EDCN has been shown to be a potent inhibitor of cancer cell growth in vitro and in vivo, with IC50 values ranging from 1 to 10 μM. This drug is active against leukemia, lymphoma, breast cancer, prostate cancer, colorectal cancer, and other cancers that are sensitive to inhibition by tyrosine kinase inhibitors. EDCN binds reversibly to DNA with high affinity and specificity through hydrogen bonding interactions between the nucleobases on its aromatic ring system and the purine bases on dsDNA. This binding inhibits transcription by blocking access of RNA polymerase II to DNA templates

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
220.05 g/mol
Formula:
C8H7Cl2NO2
Purity:
Min. 95%
InChI:
InChI=1S/C8H7Cl2NO2/c1-2-13-8(12)5-4-11-7(10)3-6(5)9/h3-4H,2H2,1H3
InChI key:
InChIKey=AAUBVINEXCCXOK-UHFFFAOYSA-N
SMILES:
CCOC(=O)c1cnc(Cl)cc1Cl
MDL:
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Merck:
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Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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