3D-FEA31540 - 24-dichloro-5-chloromethylthiazole

2-Chloro-5-chloromethylthiazole is an aliphatic hydrocarbon that has been used to chlorinate a variety of organic compounds. It reacts with hydrochloric acid and chlorine at low energy, producing chloride in the process. This chemical can be synthesized by reacting n-dimethyl formamide with hydrogen chloride. 2-Chloro-5-chloromethylthiazole can also be used as a crosslinking agent to react with the amine groups on proteins.

2-Amino-4-chloromethylthiazole (2ACMT) has been shown to be an effective antifilarial agent in pyridinium, acanthocheilonema, and refluxed mice. 2ACMT is a nucleophilic compound that binds to the active site of the enzyme DNA gyrase, inhibiting DNA synthesis. This drug also has antibacterial activity, which may be due to its ability to inhibit protein synthesis in bacteria.