Fmoc-Met-OH

CAS: 71989-28-1

Ref. 3D-FF06001

Product Information

• Name: Fmoc-Met-OH
• Synonyms: Fmoc-L-methionine, (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanylbutanoic acid, (2S)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-4-(methylsulfanyl)butanoic acid, (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-(methylsulfanyl)butanoic acid, (2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-(methylsulfanyl)butanoate, (S)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]-4-methylsulfanylbutanoic acid, (S)-N-Fmoc-methionine, 224: PN: US20070042401 PAGE: 30 claimed protein, 915: PN: WO2006135786 PAGE: 59 claimed protein, <span class="text-smallcaps">L</span>-Fmoc-Methionine, <span class="text-smallcaps">L</span>-Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, FMOC-methionine, Fmoc-L-Met-OH, N-(9-Fluorenylmethoxycarbonyl)-<span class="text-smallcaps">L</span>-methionine, N-(9-Fluorenylmethoxycarbonyl)-L-methionine, N-(9-Fluorenylmethoxycarbonyl)methionine, N-Fluorenylmethoxycarbonyl-<span class="text-smallcaps">L</span>-methionine, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-<span class="text-smallcaps">L</span>-methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine, N-alpha-FMOC-L-methionine, NSC 334292

Description

Fmoc-Met-OH is an amino acid that has significant cytotoxicity. It is a neutral molecule with a pKa of 7.6, and is soluble in water at low pH. The hydrogen bonding interactions of Fmoc-Met-OH are strong and involve the amino group and the side chain carboxyl groups, as well as other hydrophobic interactions with aromatic rings. Fmoc-Met-OH is also an acid analysis reagent for chlorine atoms because it can be easily converted to methoxychlor (CHClO). Fmoc-Met-OH has been shown to inhibit epidermal growth factor receptor signaling and has been used to block epidermal growth factor induced cell cycle progression in cancer cells.

• Brand: Biosynth

Chemical properties

• Molecular weight: 371.5 g/mol
• Formula: C₂₀H₂₁NO₄S
• Purity: Min. 98 Area-%
• Color/Form: White Powder
• InChI: InChI=1S/C20H21NO4S/c1-26-11-10-18(19(22)23)21-20(24)25-12-17-15-8-4-2-6-13(15)14-7-3-5-9-16(14)17/h2-9,17-18H,10-12H2,1H3,(H,21,24)(H,22,23)/t18-/m0/s1
• InChI key: InChIKey=BUBGAUHBELNDEW-SFHVURJKSA-N
• SMILES: CSCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O