Flindersine

CAS: 523-64-8

Ref. 3D-FF157195

Product Information

• Name: Flindersine
• Synonyms: 2,2'-Dimethyl-a-pyrano(5',6',3,4)-2(1H)-quinolone, 2,2-Dimethyl-2H-pyrano[3,2-c]quinolin-5(6H)-one, 2,6-Dihydro-2,2-dimethyl-5H-pyrano[3,2-c]quinolin-5-one, 2H-pyrano[3,2-c]quinolin-5-ol, 2,2-dimethyl-, 5H-pyrano[3,2-c]quinolin-5-one, 2,6-dihydro-2,2-dimethyl-, NSC 94655

Description

Flindersine is a coumarin derivative that has been found to have cytotoxic properties. Flindersine binds to nucleic acids, causing strand breaks in DNA and inhibiting RNA synthesis. It is also known to inhibit the growth of cervical cancer cells by inducing cell cycle arrest. The cytotoxicity of flindersine has been shown in culture systems and in animal models of leukemia. The mechanism of action on hematopoietic cells is based on the ability of flindersine to bind to DNA and form covalent bonds with the guanine residues. This inhibits DNA replication, leading to cell death.

• Brand: Biosynth

Chemical properties

• Molecular weight: 227.26 g/mol
• Formula: C₁₄H₁₃NO₂
• Purity: Min. 95%
• InChI: InChI=1S/C14H13NO2/c1-14(2)8-7-10-12(17-14)9-5-3-4-6-11(9)15-13(10)16/h3-8H,1-2H3,(H,15,16)
• InChI key: InChIKey=PXNMNABLQWUMCX-UHFFFAOYSA-N
• SMILES: CC1(C)C=Cc2c(c3ccccc3[nH]c2=O)O1