Fmoc-Ser(tBu)-OH

CAS: 71989-33-8

Ref. 3D-FF15777

Product Information

• Name: Fmoc-Ser(tBu)-OH
• Synonyms: Fmoc-O-tert-butyl-L-serineN-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-serineFmoc-L-Ser(tBu)-OH
• Brand: Biosynth
• Description: Fmoc-Ser(tBu)-OH is a synthetic amino acid that is used in the synthesis of degarelix acetate, an amide ester of the vasodilator, prostaglandin F2α. Degarelix acetate binds to the fibrinogen receptor on the surface of cells and inhibits platelet aggregation. This drug has been shown to be effective in treating prostate cancer by inhibiting epidermal growth factor receptor signaling. It also has immune modulating effects by binding to monoclonal antibodies and altering antibody responses. Fmoc-Ser(tBu)-OH is synthesized from the amino acid serine and t-butyl alcohol, which are combined with trifluoroacetic acid (TFA) and hydroxyl group. The resulting product is then reacted with dansyl chloride or benzoyl chloride (BzCl), which cleaves off one carboxylic acid group from serine, forming an

Chemical properties

• Molecular weight: 383.44 g/mol
• Formula: C₂₂H₂₅NO₅
• Purity: Min. 98 Area-%
• Color/Form: White Off-White Powder