Fmoc-Ile-OH

CAS: 71989-23-6

Ref. 3D-FF15881

Product Information

• Name: Fmoc-Ile-OH
• Synonyms: (2S,3R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-methylpentanoate, (2S,3S)-2-(((9-Fluorenylmethoxy)carbonyl)amino)-3-methylpentanoic acid, 2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-3-methylpentanoic acid, <span class="text-smallcaps">L</span>-Isoleucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, Fmoc-L-isoleucine, Fmoc-lle-OH, N-(9-Fluorenylmethoxycarbonyl)-<span class="text-smallcaps">L</span>-isoleucine, N-(9-Fluorenylmethoxycarbonyl)isoleucine, N-Fmoc-<span class="text-smallcaps">L</span>-isoleucine, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-<span class="text-smallcaps">L</span>-isoleucine, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]isoleucin, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]isoleucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alloisoleucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-isoleucine, NSC 334289, isoleucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

Description

Fmoc-Ile-OH is a cyclic peptide that has shown cytotoxic activity against cultured human brain cells. It is also an inhibitor of dipeptidyl peptidase IV (DPP-IV) and inhibits the breakdown of proteins in the brain, such as insulin. Fmoc-Ile-OH binds to the active site of DPP-IV and prevents it from binding to its substrate, thereby inhibiting the enzyme's activity. The inhibition of DPP-IV leads to increased levels of protein in the brain, which may be beneficial for people with Alzheimer's disease. Fmoc-Ile-OH is synthesized on a solid phase by coupling an amino acid with a protected carboxylic acid to yield a protected amide. This product can be used as an encapsulating agent for atosiban, a drug that is used to treat preterm labor.END>>

• Brand: Biosynth

Chemical properties

• Molecular weight: 353.41 g/mol
• Formula: C₂₁H₂₃NO₄
• Purity: Min. 98 Area-%
• Color/Form: White Off-White Powder
• InChI: InChI=1S/C21H23NO4/c1-3-13(2)19(20(23)24)22-21(25)26-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18-19H,3,12H2,1-2H3,(H,22,25)(H,23,24)/t13-,19-/m0/s1
• InChI key: InChIKey=QXVFEIPAZSXRGM-DJJJIMSYSA-N
• SMILES: CC[C@H](C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O