5-Fluoro D,L-tryptophan

CAS: 154-08-5

Ref. 3D-FF23354

Product Information

• Name: 5-Fluoro D,L-tryptophan
• Synonyms: DL-5-FluorotryptophanNSC 9363

Description

5-Fluoro D,L-tryptophan (5FDTL) is a tryptophan analog that inhibits the growth of bacteria by binding to fatty acid synthesis enzymes. 5FDTL binds to wild-type and resistant mutants of bacterial fatty acid synthases, which are proteins that catalyze the formation of long-chain fatty acids from acetyl-CoA. This binding prevents the formation of long-chain fatty acids, which are required for bacterial cell replication. 5FDTL also binds to protein data and has been shown to have an anti-infective effect on wild-type strains of Pseudomonas aeruginosa and Escherichia coli as well as Pichia pastoris. Disulfide bonds in 5FDTL stabilize its secondary structure and provide protection against proteolytic degradation by enzymes in the extracellular environment. The structural analysis of 5FDTL has revealed that it consists of a small molecule with a logarithmic growth phase

• Brand: Biosynth

Chemical properties

• Molecular weight: 222.22 g/mol
• Formula: C₁₁H₁₁FN₂O₂
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C11H11FN2O2/c12-7-1-2-10-8(4-7)6(5-14-10)3-9(13)11(15)16/h1-2,4-5,9,14H,3,13H2,(H,15,16)
• InChI key: InChIKey=INPQIVHQSQUEAJ-UHFFFAOYSA-N
• SMILES: NC(Cc1c[nH]c2ccc(F)cc12)C(=O)O