Product Information
- GW-433908GLexivaTelzir
- Calcium [(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-1-phenyl-3-phosphonatooxy-butan-2-yl]carbamate
- Carbamic acid, [(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]-, C-[(3S)-tetrahydro-3-furanyl] ester, calcium salt (1:1)
- Gw 433908G
- Lexiva
- Telzir
- calcium (2R,3S)-1-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-4-phenyl-3-({[(3S)-tetrahydrofuran-3-yloxy]carbonyl}amino)butan-2-yl phosphate
- carbamic acid, N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]-, (3S)-tetrahydro-3-furanyl ester, calcium salt (1:1)
Fosamprenavir calcium salt is a prodrug of the antiviral drug amprenavir that is converted to amprenavir in human serum. It is used in combination with other drugs for the treatment of HIV infection. Fosamprenavir calcium salt has a high degree of cytotoxicity, which may be due to its ability to inhibit activation of toll-like receptor 4 and its downstream signaling pathways. In addition, fosamprenavir calcium salt has been shown to inhibit benzalkonium chloride-induced neutrophil chemotaxis, suggesting that it may have anti-inflammatory effects. Fosamprenavir calcium salt also binds to pharmacological agents such as cyclosporine, erythromycin, and indinavir sulfate through competitive inhibition. This binding prevents the formation of an active complex with the enzyme UGT1A4 that is required for glucuronidation and excretion from the body.
Chemical properties
Technical inquiry about: 3D-FF23594 Fosamprenavir calcium salt
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