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CAS 226700-81-8

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Fosamprenavir calcium

Description:
Fosamprenavir calcium is a prodrug of amprenavir, primarily used as an antiretroviral medication in the treatment of HIV infection. It is classified as a protease inhibitor, which works by inhibiting the HIV protease enzyme, thereby preventing viral replication. The compound is characterized by its calcium salt form, which enhances its solubility and bioavailability. Fosamprenavir is typically administered orally and is often used in combination with other antiretroviral agents to improve therapeutic efficacy and reduce the risk of resistance. The substance is known for its favorable pharmacokinetic profile, including a relatively long half-life, allowing for once or twice daily dosing. Common side effects may include gastrointestinal disturbances, rash, and potential interactions with other medications due to its metabolism via the cytochrome P450 system. Overall, fosamprenavir calcium plays a significant role in the management of HIV, contributing to improved patient outcomes when used as part of a comprehensive antiretroviral therapy regimen.
Formula:C25H34CaN3O9PS
InChI:InChI=1/C25H36N3O9PS.Ca/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21;/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32);/q;+2/t21-,23-,24+;/m0./s1
InChI key:InChIKey=XOGQXKBFJZURRD-HQROKSDRSA-N
SMILES:[C@H]([C@H](CC1=CC=CC=C1)NC(O[C@H]2CCOC2)=O)(CN(S(=O)(=O)C3=CC=C(N)C=C3)CC(C)C)OP(=O)(O)O.[Ca]
Synonyms:
  • Calcium [(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-1-phenyl-3-phosphonatooxy-butan-2-yl]carbamate
  • Carbamic acid, [(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]-, C-[(3S)-tetrahydro-3-furanyl] ester, calcium salt (1:1)
  • Fosamprenavir calcium salt
  • Gw 433908G
  • Lexiva
  • Telzir
  • calcium (2R,3S)-1-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-4-phenyl-3-({[(3S)-tetrahydrofuran-3-yloxy]carbonyl}amino)butan-2-yl phosphate
  • carbamic acid, N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]-, (3S)-tetrahydro-3-furanyl ester, calcium salt (1:1)
  • Fosamprenavir calcium
  • FOSAMPRENAVIR
  • See more synonyms
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