6-Fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid

CAS: 96187-53-0

Ref. 3D-FF44184

Product Information

• Name: 6-Fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid
• Synonyms: 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro(1,1'-biphenyl)-4-yl)-3-methyl-, 6-Fluoro-2-(2'-Fluorobiphenyl-4-Yl)-3-Methylquinoline-4-Carboxylic Acid, 6-Fluoro-2-(2′-fluoro[1,1′-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid, Biphenquinate, Brequinar [INN], Brequinarum, Brequinarum [INN-Latin], Dup 785, Unii-5Xl19F49H6, brequinarum [Latin]

Description

Brequinar sodium is a drug that belongs to the class of quinoline carboxylic acid derivatives. It has been shown to be effective in the treatment of infectious diseases and bowel disease. Brequinar sodium inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Brequinar also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

• Brand: Biosynth

Chemical properties

• Molecular weight: 375.37 g/mol
• Formula: C₂₃H₁₅F₂NO₂
• Purity: Min. 97 Area-%
• Color/Form: White/Off-White Solid
• InChI: InChI=1S/C23H15F2NO2/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25/h2-12H,1H3,(H,27,28)
• InChI key: InChIKey=PHEZJEYUWHETKO-UHFFFAOYSA-N
• SMILES: Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(=O)O