5-Fluoro-D-Tryptophan

CAS: 97749-24-1

Ref. 3D-FF52377

Product Information

• Name: 5-Fluoro-D-Tryptophan
• Synonyms: (R)-2-Amino-3-(5-fluoro-1H-indol-3-yl)propionic acid, 5-Fluoro-D-tryptophan, D-5-Fluorotryptophan

Description

5-Fluoro-D-Tryptophan is a fluorescent substrate for the enzyme indoleamine 2,3 dioxygenase (IDO) that is used in assays to determine the activity of this enzyme. IDO is an enzyme that is found in animals and catalyzes the first step in tryptophan metabolism by converting it to 5-fluoro-kynurenine. The amount of fluorescence generated can be detected with a fluorescence detector. 5-Fluoro-D-Tryptophan has been shown to have higher levels of uptake by tumor tissue than by normal tissue, which may be due to its ability to inhibit protein synthesis and cell division.

• Brand: Biosynth

Chemical properties

• Molecular weight: 222.22 g/mol
• Formula: C₁₁H₁₁FN₂O₂
• Purity: Min. 95%
• Color/Form: White/Off-White Solid
• InChI: InChI=1S/C11H11FN2O2/c12-7-1-2-10-8(4-7)6(5-14-10)3-9(13)11(15)16/h1-2,4-5,9,14H,3,13H2,(H,15,16)/t9-/m1/s1
• InChI key: InChIKey=INPQIVHQSQUEAJ-SECBINFHSA-N
• SMILES: N[C@H](Cc1c[nH]c2ccc(F)cc12)C(=O)O