3D-FF52546 - fmoc-erythro-beta-phenylserine | 1217667-13-4

A building block of peptide antibiotics and a valuable chiral synthon. Crich and Banerjee used it for obtaining β-mercaptophenylalanine. Introduction of this Phe derivative allowed native chemical ligation at Phe followed by desulfuration.

<p>DL-threo-3-Phenylserine hydrate</p>

<p>(2R,3S)-3-Phenylserine</p>

<p>Applications L-threo-Phenylserine is a valuable chiral synthon.<br></p>

<p>(2R,3S)-3-Phenylserine is a copper complex of an ester hydrochloride that has been used in the synthesis of proteins. The asymmetric synthesis of this molecule was achieved by using hydrogen fluoride as a catalyst and high salt as an additive. (2R,3S)-3-Phenylserine has also been shown to be a substrate for racemase, which converts it to its natural form - L-phenylalanine. (2R,3S)-3-Phenylserine has been used in tissue culture studies to produce proteins from amino acids. (2R,3S)-3-Phenylserine is also known to have a neutral ph and can be found in agarose gels.</p>

<p>L-threo-Phenylserine is a naturally occurring amino acid that is synthesized in the human body. It can be found in the brain and muscles, where it is used for protein synthesis. L-threo-phenylserine has been shown to be an effective oxygen nucleophile and can catalyze the hydrolysis of hydrogen fluoride. This compound has also been shown to have biological activity in vitro as well as structural properties that are useful for conformational analysis and structural biology research. L-threo-phenylserine may also have potential medical applications, such as its use as a treatment for mental disorders and epilepsy.</p>

<p>Applications 2-amino-3-hydroxy-3-phenylpropanoic acid (cas# 7695-56-9) is a useful research chemical.<br></p>

<p>Applications DL-3-Phenylserine hydrate is the hydrate of DL-β-Phenylserine, threo form (P319380). DL-beta-Phenylserine, threo form is used in the enantioselective synthesis of cyclic pentapeptides. This compound also showed analgesic activity in mice when the mice were pretreated with pargyline.<br>References Le, Diane N, et al.: Organic Letters, 19(1), 114-117 (2017); Matsuoka, Yutaka, et al.: Jap. J. of Pharmacology, 34(3), 277-87 (1984)<br></p>

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