Fmoc-β-cyclohexyl-D-alanine

CAS: 144701-25-7

Ref. 3D-FF55913

Product Information

• Name: Fmoc-β-cyclohexyl-D-alanine
• Synonyms: Fmoc-D-Cha-OHFmoc-3-cyclohexyl-D-alanine, (2R)-3-Cyclohexyl-2-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)propanoic acid, (αR)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]cyclohexanepropanoic acid, 3-cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-alanine, Cyclohexanepropanoic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (R)-, Cyclohexanepropanoic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (αR)-, Fmoc-(R)-3-Cyclohexylalanine, Fmoc-.beta.-cyclohexyl-D-Ala-OH, Fmoc-D-Cha-OH, N-alpha-(9-fluorenylmethyloxycarbonyl)-D-cyclohexylalanine

Description

Fmoc-beta-cyclohexyl-D-alanine is a fragment of the cyclic peptide cyclohexylalanine and has been shown to inhibit cell growth in culture. It binds to DNA in a transcriptional manner and induces apoptosis, which is characterized by dna fragmentation. Fmoc-beta-cyclohexyl-D-alanine also inhibits extracellular signal-regulated kinase (ERK) activity, leading to reduced expression of antiapoptotic proteins such as Bcl2 and BclXL. This drug has been shown to induce apoptosis in cells that have been transfected with an antiapoptotic vector.

• Brand: Biosynth

Chemical properties

• Molecular weight: 393.48 g/mol
• Formula: C₂₄H₂₇NO₄
• Purity: Min. 95%
• InChI: InChI=1S/C24H27NO4/c26-23(27)22(14-16-8-2-1-3-9-16)25-24(28)29-15-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21/h4-7,10-13,16,21-22H,1-3,8-9,14-15H2,(H,25,28)(H,26,27)/t22-/m1/s1
• InChI key: InChIKey=HIJAUEZBPWTKIV-JOCHJYFZSA-N
• SMILES: O=C(N[C@H](CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21