3-Fluorobenzoyl chloride

CAS: 1711-07-5

Ref. 3D-FF57586

Product Information

• Name: 3-Fluorobenzoyl chloride
• Synonyms: 3-Fluoro-Benzoylchloride, 3-Fluorobenzenecarbonyl chloride, 3-Fluorobenzoxyl chloride, 3-Fluorobenzoylchloride, Akos Bbs-00003915, Benzoyl chloride, 3-fluoro-, Benzoyl chloride, m-fluoro-, Fluorobenzoylchloride, NSC 88315, m-Fluorobenzoic acid chloride, m-Fluorobenzoyl chloride, meta-Fluorobenzoyl chloride

Description

3-Fluorobenzoyl chloride is an inhibitor of AMPK. It binds to the ATP-binding site of the enzyme and inhibits phosphorylation, leading to decreased activity. 3-Fluorobenzoyl chloride has been shown to reduce the growth of cancer cells in vitro and in vivo by increasing the levels of a protein called p27KIP1. This protein regulates cell cycle progression and prevents cancer cells from entering into mitosis. 3-Fluorobenzoyl chloride also binds to factor receptors and inhibits kinase selectivity, which causes increased glucose uptake in adipocytes. The fluorine atom on this molecule increases its lipophilicity, which makes it more potent than other inhibitors that do not contain fluorine atoms.

• Brand: Biosynth

Chemical properties

• Molecular weight: 158.56 g/mol
• Formula: C₇H₄ClFO
• Purity: Min. 95%
• InChI: InChI=1S/C7H4ClFO/c8-7(10)5-2-1-3-6(9)4-5/h1-4H
• InChI key: InChIKey=SYVNVEGIRVXRQH-UHFFFAOYSA-N
• SMILES: O=C(Cl)c1cccc(F)c1