Product Information
- 1-(2-Chloro-6-Fluorobenzyl)-1,4-Diazepane
- 3-Methoxy-4-fluorobenzonitrile
- Benzonitrile, 4-fluoro-3-methoxy-
4-Fluoro-3-methoxybenzonitrile (4FM) is an orally active dihydrobenzofuran derivative that has been optimized for oral bioavailability. The drug is a potent inhibitor of efflux and can be used to lower the oral bioavailability of drugs that are substrates for efflux. 4FM also inhibits heterocycle metabolism, which can be used as a strategy to evolve drugs with improved physicochemical properties. 4FM has shown preclinical efficacy in lowering heterocycle levels, including lowering of methadone levels in humans. The drug is a competitive inhibitor of the enzyme P450 2D6, which is responsible for the metabolism of many drugs. This inhibition may have adverse effects on these drugs and should be monitored closely during treatment with 4FM.
Chemical properties
Technical inquiry about: 3D-FF70468 4-Fluoro-3-methoxybenzonitrile
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