3-Fluorobenzyl isocyanate

CAS: 102422-56-0

Ref. 3D-FF96949

Product Information

• Name: 3-Fluorobenzyl isocyanate
• Synonyms: 1-Fluoro-3-(isocyanatomethyl)benzene, 5-Fluorobenzylisocyanate, Benzene, 1-fluoro-3-(isocyanatomethyl)-

Description

3-Fluorobenzyl isocyanate is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β). GSK-3β is a serine/threonine protein kinase that plays an important role in the regulation of glycogen metabolism, cell cycle progression, and apoptosis. 3-Fluorobenzyl isocyanate blocks the phosphorylation site on GSK-3β's ATP binding site and inhibits its activity. This drug also has inhibitory effects on x-ray irradiation induced hyperphosphorylation of tau protein in Alzheimer's disease patients. 3-Fluorobenzyl isocyanate has been shown to form co-crystals with oxadiazole derivatives, which may be due to their structural similarity. The co-crystal structure of 3-fluorobenzyl isocyanate and oxadiazole derivatives was determined using x-ray diff

• Brand: Biosynth

Chemical properties

• Molecular weight: 151.14 g/mol
• Formula: C₈H₆FNO
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C8H6FNO/c9-8-3-1-2-7(4-8)5-10-6-11/h1-4H,5H2
• InChI key: InChIKey=PHRJTGPFEAUEBC-UHFFFAOYSA-N
• SMILES: O=C=NCc1cccc(F)c1