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Duocarmycin sa
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Duocarmycin sa

CAS: 130288-24-3

Ref. 3D-FFA28824

10mgTo inquire
Estimated delivery in United States, on Friday 3 Jan 2025

Product Information

Name:
Duocarmycin sa
Synonyms:
  • Antibiotic DC 113
  • Cyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylic acid, 1,2,4,5,8,8a-hexahydro-4-oxo-2-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-, methyl ester, (7bR)-
  • Cyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylic acid, 1,2,4,5,8,8a-hexahydro-4-oxo-2-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-, methyl ester, (7bR,8aS)-
  • Cyclopropacpyrrolo3,2-eindole-6-carboxylic acid, 1,2,4,5,8,8a-hexahydro-4-oxo-2-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (7bR)-
  • methyl (3bR,4aS)-8-oxo-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-1,4,4a,5,6,8-hexahydrocyclopropa[c]pyrrolo[3,2-e]indole-2-carboxylate
Description:

Duocarmycin SA is a monoclonal antibody that binds to the hydroxyl group of duocarmycin A and B. It has been shown to have potent antitumor activity against solid tumours. Duocarmycin SA also induces apoptosis in cancer cells by blocking the epidermal growth factor receptor, which leads to the activation of caspases and cleavage of poly ADP-ribose polymerase (PARP). This binding prevents the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division.

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
477.5 g/mol
Formula:
C25H23N3O7
Purity:
Min. 95%
MDL:
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EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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