H-D-Glu(Gly-OH)-OH

CAS: 6729-55-1

Ref. 3D-FG108033

Product Information

• Name: H-D-Glu(Gly-OH)-OH
• Synonyms: H-gamma-D-Glu-Gly-OH DGG gamma-DGG, (2R)-2-Amino-5-(carboxymethylamino)-5-oxopentanoic acid, (2R)-2-ammonio-5-[(carboxylatomethyl)amino]-5-oxopentanoate, <span class="text-smallcaps">D</span>-γ-Glutamylglycine, Glutamine, N-(carboxymethyl)-, <span class="text-smallcaps">D</span>-, Glycine, <span class="text-smallcaps">D</span>-γ-glutamyl-, Glycine, N-<span class="text-smallcaps">D</span>-γ-glutamyl-, Glycine, N-D-gamma-glutamyl-, H-D-Glu(Gly-Oh)-Oh, L-gamma-glutamylglycine, gamma-D-Glutamylglycine, γ-<span class="text-smallcaps">D</span>-Glutamylglycine, D-γ-Glutamylglycine, Glutamine, N-(carboxymethyl)-, D-, γ-D-Glutamylglycine, Glycine, N-D-γ-glutamyl-, Glycine, D-γ-glutamyl-

Description

H-D-Glu(Gly-OH)-OH is a peptide that is used to study the mechanism of glutamate receptors. It has been shown to have an excitatory effect on mouse hippocampal and cerebellar purkinje neurons, with affinity values for membrane channels. It also has been shown to reduce gamma-aminobutyric acid (GABA) levels in the hippocampus and striatum, which may be due to its ability to inhibit glutamic acid decarboxylase. H-D-Glu(Gly-OH)-OH is a potent antagonist of glutamate, binding competitively at the glutamate site on ionotropic receptors. It also inhibits acidic pH and calcium ion concentrations, which are necessary for ionotropic receptor activation.

• Brand: Biosynth

Chemical properties

• Molecular weight: 204.18 g/mol
• Formula: C₇H₁₂N₂O₅
• Purity: Min. 98 Area-%
• Color/Form: White Powder
• InChI: InChI=1S/C7H12N2O5/c8-4(7(13)14)1-2-5(10)9-3-6(11)12/h4H,1-3,8H2,(H,9,10)(H,11,12)(H,13,14)/t4-/m1/s1
• InChI key: InChIKey=ACIJGUBIMXQCMF-SCSAIBSYSA-N
• SMILES: N[C@H](CCC(=O)NCC(=O)O)C(=O)O