(+)-Glaucine

CAS: 475-81-0

Ref. 3D-FG65865

Product Information

• Name: (+)-Glaucine
• Synonyms: 1,2,9,10-TetramethoxyaporphineBoldine dimethyletherGlaucine, (6aS)-1,2,9,10-Tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline, (6aS)-5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo[de,g]quinoline, (S)-5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo[de,g]quinoline, (S)-Glaucine, 4H-Dibenzo[de,g]quinoline, 5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-, (S)-, 4H-dibenzo[de,g]quinoline, 5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-, (6aS)-, 6a.alpha.-Aporphine, 1,2,9,10-tetramethoxy-, 6aα-Aporphine, 1,2,9,10-tetramethoxy-, Boldine Dimethyl Ether, Bromcholitin, Glauvent, N,O,O′-Trimethyllaurelliptine, NSC 34396, O,O-Dimethylboldine, O,O-Dimethylisoboldine, d-Glaucine
• CAS: 475-81-0

Description

(+)-Glaucine is a biologically active molecule that is used in the treatment of chronic cough. It has been shown to inhibit the production of inflammatory cytokines and chemokines, such as IL-8 and TNF-α. (+)-Glaucine also inhibits toll-like receptor (TLR) signaling, which is involved in the activation of inflammatory response. (+)-Glaucine binds to 5HT2 receptors on human polymorphonuclear leukocytes and blocks their activation by suppressing NF-κB activity. The drug has been shown to have anti-inflammatory effects on mouse tumor cells and curcuma aromatica cells, where it inhibits DNA intercalation.

• Brand: Biosynth

Chemical properties

• Molecular weight: 355.43 g/mol
• Formula: C₂₁H₂₅NO₄
• Purity: Min. 95%
• Color/Form: Off-White Powder
• InChI: InChI=1S/C21H25NO4/c1-22-7-6-12-9-18(25-4)21(26-5)20-14-11-17(24-3)16(23-2)10-13(14)8-15(22)19(12)20/h9-11,15H,6-8H2,1-5H3/t15-/m0/s1
• InChI key: InChIKey=RUZIUYOSRDWYQF-HNNXBMFYSA-N
• SMILES: COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3