glaucocalyxin A
CAS: 79498-31-0
Ref. 3D-FG73922
| 2mg | Discontinued | ||
| 5mg | Discontinued | ||
| 10mg | Discontinued | ||
| 25mg | Discontinued | ||
| 50mg | Discontinued |
Product Information
- (5Beta,7Alpha,9Beta,10Alpha)-7,14-Dihydroxykaur-16-Ene-3,15-Dione
- (7α,14R)-7,14-Dihydroxykaur-16-ene-3,15-dione
- 7H-2,10a-Ethanophenanthrene, kaur-16-ene-3,15-dione deriv.
- Kaur-16-ene-3,15-dione, 7,14-dihydroxy-, (7α,14R)-
- Leucamenin F
- Wangzaozin B
- leukamenin F
- Glaucocalyxin A
Glaucocalyxin A, a natural product, is a cytotoxic agent that binds to the matrix effect and mitochondria membrane potential. This compound has been shown to have significant cytotoxicity in HL-60 cells and K562 cells. Glaucocalyxin A also induces oxidative injury by increasing the mitochondrial membrane potential and reducing the amount of ATP produced by mitochondria. In addition, this compound has been shown to possess anti-cancer properties and may be used as an anticancer drug. Glaucocalyxin A enhances the production of pro-apoptotic protein Bax and inhibits growth factor-β1 (GF-β1), which is a cytokine that regulates cellular proliferation and differentiation.
Glaucocalyxin A also causes apoptosis by inhibiting the polymerase chain reaction (PCR) process in DNA synthesis. The biological properties of glaucocalyxin A are due to its ability to inhibit DNA replication and transcriptional activity.br>br>
