HBTU

CAS: 94790-37-1

Ref. 3D-FH07095

Product Information

• Name: HBTU
• Synonyms: N,N,N',N'-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphateO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate
• Brand: Biosynth
• Description: HBTU is a common reagent used for peptide coupling, which can be employed for amide and ester formation. It is stable, highly reactive, suitable for solid phase and in-solution synthesis. The major advantages of HBTU are high yields, fast reaction times, easy reaction conditions, racemisation control and ease of purification from the water-soluble by-products. HBTU contains both the carbodiimide function and the benzotriazole one, activating the carboxylic acid and forming HOBt in situ. Although HBTU was originally catalogued as uronium salt, X-ray diffraction showed evidence for it to be an aminium salt instead.

Chemical properties

• Molecular weight: 379.24 g/mol
• Formula: C₁₁H₁₆F₆N₅OP
• Purity: Min. 99 Area-%
• Color/Form: White Powder