Hydroxyurea

CAS: 127-07-1

Ref. 3D-FH09735

Product Information

• Name: Hydroxyurea
• Synonyms: Hydroxycarbamide, 1-Hydroxyurea, Amino(Oxido-Λ5-Azanyl)Methanone, Biosupressin, Carbamohydroxamic acid, Carbamohydroximic acid, Carbamoyl oxime, Carbamyl hydroxamate, Cytodrox, Droxia, HU, Hidrix, Hidroxicarbamida, Hydrea, Hydreia, Hydrixycarbamide, Hydroxy Urea (D4), Hydroxy urea, Hydroxycarbamid, Hydroxycarbamine, Hydroxylamine, N-(aminocarbonyl)-, Hydroxylurea, Hydura, Hydurea, Litaler, Litalir, Mylocel, N-(aminocarbonyl)hydroxylamine, N-Carbamoylhydroxylamine, N-Hydroxyharnstoff, N-Hydroxyurea, Nci C04831, Nsc 32065, Onco-carbide, Oxyrea, Oxyurea, Siklos, Sk 22591, Sq 1089, Urea, N-hydroxy-, Urea, hydroxy-, Wr 83799, Xromi

Description

Hydroxyurea is a prodrug that is activated by the enzyme Jak2, which is found in the mitochondria of cells. Hydroxyurea is used to treat various types of cancer and other diseases, such as sickle cell anemia. It has been shown to be effective in inhibiting the growth of squamous cell carcinomas and myeloid leukemia cells. Hydroxyurea has also been shown to have synergistic effects when combined with other pharmacological agents, such as hydroxycarbamide and cytosine arabinoside. Hydroxyurea inhibits the production of energy in the form of ATP, which leads to death by apoptosis or necrosis. This drug also has inhibitory properties against bacterial infections, especially those caused by Mycobacterium tuberculosis and Mycobacterium avium complex.

• Brand: Biosynth

Chemical properties

• Molecular weight: 76.06 g/mol
• Formula: CH₄N₂O₂
• Purity: Min. 97.5 Area-%
• Color/Form: White Off-White Powder
• InChI: InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
• InChI key: InChIKey=VSNHCAURESNICA-UHFFFAOYSA-N
• SMILES: NC(=O)NO