(R)-(+)-9-(2-Hydroxypropyl)adenine

CAS: 14047-28-0

Ref. 3D-FH10709

Product Information

• Name: (R)-(+)-9-(2-Hydroxypropyl)adenine
• Synonyms: (2R)-1-(6-Aminopurin-9-yl)propan-2-ol, (2R)-1-(6-amino-9H-purin-9-yl)propan-2-ol, (R)-(+)-9-(2-Hydroxypropyl)adenine(PMP), (αR)-6-Amino-α-methyl-9H-purine-9-ethanol, 6-Amino-alpha-methyl-9H-purine-9-ethanol, 9-[(2R)-2-Hydroxypropyl]adenine, 9-[2-(R)-(Hydroxy)propyl]adenine, 9H-Purine-9-ethanol, 6-amino-α-methyl-, (R)-, 9H-Purine-9-ethanol, 6-amino-α-methyl-, (αR)-, 9H-Purine-9-ethanol, 6-amino-α-methyl-, <span class="text-smallcaps">D</span>-, <span class="text-smallcaps">D</span>-(-)-9-(2-Hydroxypropyl)adenine, D-(-)-9-(2-Hydroxypropyl)adenine, Hydroxypropyl adenine

Description

(R)-(+)-9-(2-Hydroxypropyl)adenine (HPA) is a carbocyclic nucleoside that has been shown to be effective against the human immunodeficiency virus (HIV). HPA inhibits the reverse transcriptase and integrase enzymes, which are necessary for HIV replication. It also inhibits phosphorylation of host cell proteins, leading to decreased viral protein synthesis. The reaction yield of this compound is high and it can be industrially produced with a synthetic process. HPA is synthesized from adenosine by the addition of two hydroxyl groups on the adjacent carbon atoms. HPA has a low energy ring-opening reaction with hydrogen chloride, which leads to its potent inhibition of HIV infection.

• Brand: Biosynth

Chemical properties

• Molecular weight: 193.21 g/mol
• Formula: C₈H₁₁N₅O
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C8H11N5O/c1-5(14)2-13-4-12-6-7(9)10-3-11-8(6)13/h3-5,14H,2H2,1H3,(H2,9,10,11)/t5-/m1/s1
• InChI key: InChIKey=MJZYTEBKXLVLMY-RXMQYKEDSA-N
• SMILES: C[C@@H](O)Cn1cnc2c(N)ncnc21