Histogranin

CAS: 150045-04-8

Ref. 3D-FH108644

Product Information

• Name: Histogranin
• Synonyms: H-Met-Asn-Tyr-Ala-Leu-Lys-Gly-Gln-Gly-Arg-Thr-Leu-Tyr-Gly-Phe-OH H-MNYALKGQGRTLYGF-OH
• Brand: Biosynth
• Description: Histogranin H is a glycoprotein that is secreted by gland cells. Histogranin H has been shown to have pharmacological effects on locomotor activity and pain in animal models. This protein has also been shown to inhibit cancer growth in vitro and in vivo. In addition, it has a protective effect on the central nervous system, which may be due to its ability to increase the expression of brain-derived neurotrophic factor (BDNF). It also inhibits the proliferation of glioma cells, which are cancerous tumors that originate from glial cells in the brain. Histogranin H binds to histone proteins and glutamate receptors, which leads to an antinociceptive effect when injected into rats. The antinociceptive effect of this protein is attenuated by trypsin treatment. Histogranin H has also been shown to have an analgesic effect when injected into rats with chronic pain models.

Chemical properties

• Molecular weight: 1,718.97 g/mol
• Formula: C₇₈H₁₁₉N₂₁O₂₁S
• Purity: Min. 95%