Product Information
Name:5-Hydroxy-3-methylindole
Brand:Biosynth
Description:5-Hydroxy-3-methylindole (5HMI) is a metabolite of the drug tamoxifen, which is used for the treatment of breast cancer. It is also found in urine samples and has been shown to be reactive with cytochrome P450 2E1 (CYP2E1). 5HMI has been shown to inhibit the activity of CYP2E1 in humans, rats, and mice. 5HMI has also been shown to have anti-epileptic properties in epileptics. This active form is metabolized by adipose tissue or liver cells through oxidation and conjugation with glucuronic acid. The human liver cells show constitutive androstane receptor (CAR) activation, which may be due to its ability to act as an agonist or partial agonist.
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Chemical properties
Molecular weight:147.17 g/mol
Formula:C9H9NO
Purity:Min. 96%
Color/Form:Powder
InChI:InChI=1S/C9H9NO/c1-6-5-10-9-3-2-7(11)4-8(6)9/h2-5,10-11H,1H3
InChI key:InChIKey=NPHFOFOYWYLBTF-UHFFFAOYSA-N
SMILES:Cc1c[nH]c2ccc(O)cc12
Technical inquiry about: 5-Hydroxy-3-methylindole
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