16a-Hydroxyprednisolone

Ref. 3D-FH15933

Product Information

• Name: 16a-Hydroxyprednisolone
• Synonyms: 11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione
• Brand: Biosynth
• Description: 16a-Hydroxyprednisolone is a synthetic corticosteroid that has been used in the treatment of inflammatory diseases. It has a potency of 1/10th that of prednisolone and is used as an industrial preparation, such as for the production of plastics. 16a-Hydroxyprednisolone is prepared by reacting phthalic anhydride with hydrocortisone or hydrocortisone acetate. Impurities are removed by preparative thin-layer chromatography using silica gel plates. The product can be purified further by recrystallization from water or from chloroform/methanol mixtures. The presence of virulent microorganisms can be detected by adding a small amount to tissue samples and then examining them for signs of lysis or death. Acid catalysis is required in the sample preparation, which involves the use of an inorganic acid (e.g., hydrochloric acid) to remove any traces

Chemical properties

• Molecular weight: 376.44 g/mol
• Formula: C₂₁H₂₈O₆
• Purity: Min. 98 Area-%
• Color/Form: White Powder