1-Hydroxy-2(1H)-pyridinethione

CAS: 1121-30-8

Ref. 3D-FH175788

Product Information

• Name: 1-Hydroxy-2(1H)-pyridinethione
• Synonyms: 1-Hydroxy-1,2-dihydropyridine-2-thione, 1-Hydroxy-1H-pyridine-2-thione, 1-Hydroxy-2-(1H)-pyridinethione, 1-Hydroxy-2-pyridinethione, 1-Hydroxy-2-thiopyridinone, 1-hydroxypyridine-2(1H)-thione, 2-(1H)-Pyridinethione, 1-hydroxy-, Ai3-60234, Brn 0109936, N-Hydroxy-2-thiopyridone, N-Hydroxypyridine-2(1H)-thione, N-Hydroxypyridine-2-thione, Nsc 179790, Omadine, Pyrithione, Sq 2113, Unii-6Gk82Ec25D, 1-Hydroxyl-1H-pyridine-2-thione, 5-21-07-00150 (Beilstein Handbook Reference)

Description

1-Hydroxy-2(1H)-pyridinethione (PYR) is a metal chelate that has been shown to bind to zinc and copper with high affinity. The pyrithione form of this compound is used in the treatment of dandruff, seborrheic dermatitis, and psoriasis. It is also used for the prevention of hair loss and as an adjuvant therapy for cancer. The coordination geometry of PYR is octahedral and its cytosolic concentration is less than 1 μM. Its acute toxicity has been studied in rats, mice, and rabbits, with no deaths occurring up to doses of 2000 mg/kg. In addition to its anti-inflammatory properties, PYR has synergistic effects on cells when combined with sodium salts such as sodium sulfate or sodium chloride.

• Brand: Biosynth

Chemical properties

• Molecular weight: 127.17 g/mol
• Formula: C₅H₅NOS
• Purity: Min. 95%