20a-Hydroxy cholesterol

CAS: 516-72-3

Ref. 3D-FH23941

Product Information

• Name: 20a-Hydroxy cholesterol
• Synonyms: (3b)-Cholest-5-ene-3,20-diol
• Brand: Biosynth
• Description: 20a-Hydroxy cholesterol is a model system for studying the effects of hydroxylation on fatty acid metabolism. The addition of one hydroxyl group to the 20 carbon position in cholesterol leads to an analog, 20a-hydroxycholesterol. This compound has been shown to inhibit the enzyme activities of 3-hydroxyacyl coenzyme A dehydrogenase and acyl coenzyme A:cholesterol acyltransferase. The inhibition of these enzymes leads to decreased production of both prostaglandin E2 and leukotriene B4, which are pro-inflammatory mediators. 20a-Hydroxycholesterol has also been found to be effective in treating skin cancer and adrenocortical carcinoma by inhibiting lipid synthesis, thereby reducing cell proliferation rates.

Chemical properties

• Molecular weight: 402.65 g/mol
• Formula: C₂₇H₄₆O₂
• Purity: Min. 95%