3-Hydroxy desloratadine
CAS: 119410-08-1
Ref. 3D-FH23974
| 1mg | 172.00 € | ||
| 2mg | 217.00 € | ||
| 5mg | 356.00 € | ||
| 10mg | 451.00 € | ||
| 25mg | 673.00 € |
Product Information
- 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol3-HydroxydesloratadineSch 45581
- 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol
- Sch 45581
- 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol
- 3-Hydroxydesloratadine
3-Hydroxy desloratadine is a metabolite of desloratadine. It is one of the metabolites that can be formed from the drug in vivo, after oral administration. 3-Hydroxy desloratadine has been shown to be an active metabolite in vitro and in vivo, with linear calibration curves (R2>0.99) for both human liver and human plasma samples. The metabolic profile of 3-hydroxy desloratadine is similar to that of desloratadine, including inhibition of cytochrome P450 enzymes and glucuronidation by glucuronidases. In vitro studies have shown that 3-hydroxy desloratadine is not a substrate for CYP2D6 or CYP3A4, but it may inhibit CYP1A2 and CYP2C19. It has also been shown to be a substrate for UGT1A6 and UGT2B7.
Chemical properties
Technical inquiry about: 3D-FH23974 3-Hydroxy desloratadine
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